Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation.

Cojutti, Piergiorgio; Maximova, Natalia; Crichiutti, Giovanni; Isola, Miriam; Pea, Federico

Cojutti, Piergiorgio; Maximova, Natalia; Crichiutti, Giovanni; Isola, Miriam; Pea, Federico.

Afiliación

Cojutti P; Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
Maximova N; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Crichiutti G; Clinics of Pediatrics, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.
Isola M; Department of Medical and Biological Sciences, Section of Statistics, University of Udine, Udine, Italy.
Pea F; Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy pea.federico@aoud.sanita.fvg.it.

J Antimicrob Chemother ; 70(1): 198-206, 2015 Jan.

Article en En | MEDLINE | ID: mdl-25182066

Asunto(s)

Acetamidas/farmacocinética; Acetamidas/uso terapéutico; Antibacterianos/farmacocinética; Antibacterianos/uso terapéutico; Monitoreo de Drogas; Infecciones por Bacterias Grampositivas/tratamiento farmacológico; Oxazolidinonas/farmacocinética; Oxazolidinonas/uso terapéutico; Área Bajo la Curva; Niño; Preescolar; Femenino; Hospitalización; Humanos; Lactante; Pacientes Internos; Linezolid; Masculino; Método de Montecarlo; Plasma/química; Estudios Retrospectivos; Centros de Atención Terciaria

Palabras clave

MDR staphylococci; drug interactions; drug underexposure; oxazolidinones

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Bacterias Grampositivas / Monitoreo de Drogas / Oxazolidinonas / Acetamidas / Antibacterianos Tipo de estudio: Health_economic_evaluation / Observational_studies / Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: Italia

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