MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM.
Genes Dev
; 28(17): 1873-8, 2014 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-25184675
ABSTRACT
Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regulation as a key mechanism controlling apoptosis in the post-implantation epiblast. Moreover, we found that three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM. These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Proto-Oncogénicas
/
Apoptosis
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Regulación del Desarrollo de la Expresión Génica
/
Células Madre Pluripotentes
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MicroARNs
/
Proteínas Reguladoras de la Apoptosis
/
Proteínas de la Membrana
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2014
Tipo del documento:
Article