Molecular epidemiology and mapping of tuberculosis in Israel: do migrants transmit the disease to locals?
Int J Tuberc Lung Dis
; 18(9): 1085-91, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25189557
ABSTRACT
SETTING:
Israel receives migrants from various countries, some of which have high tuberculosis (TB) prevalence.OBJECTIVE:
To assess the predominant Mycobacterium tuberculosis strains in Israel isolated during 2008-2010 among Israeli-born and migrant patients, and to investigate possible transmission of TB from migrants to the local population.METHODS:
Molecular characterisation employed 43-spacer spoligotyping and 16-loci mycobacterial interspersed repetitive units-variable number of tandem repeats typing. All patients were classified according to those who were members of a cluster and those who were not.RESULTS:
Among 684 M. tuberculosis strains isolated from new patients genotyped and assigned to their specific cohort populations during the study period, major spoligotype families were Central Asian (CAS) (n = 140, 20%), Beijing (n = 101, 15%) and T (n = 160, 23%). Most Beijing strains (66%) were isolated from patients from the former Soviet Union (FSU), while CAS strains were mainly (74%) from Ethiopia, Eritrea and Sudan (EES). For the heterogeneous T-clade, patient countries of origin were 38% EES and 33% FSU.CONCLUSIONS:
Predominant M. tuberculosis genotypes in Israel in 2008-2010 were similar to genotypes endemic to the migrants' countries of origin. Epidemiological investigations did not demonstrate transmission between migrants and Israeli-born patients sharing the same cluster.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Trazado de Contacto
/
Emigración e Inmigración
/
Emigrantes e Inmigrantes
/
Mycobacterium tuberculosis
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2014
Tipo del documento:
Article
País de afiliación:
Israel