Biochemical characterization of New Delhi metallo-ß-lactamase variants reveals differences in protein stability.

Makena, Anne; Brem, Jürgen; Pfeffer, Inga; Geffen, Rebecca E J; Wilkins, Sarah E; Tarhonskaya, Hanna; Flashman, Emily; Phee, Lynette M; Wareham, David W; Schofield, Christopher J

Makena, Anne; Brem, Jürgen; Pfeffer, Inga; Geffen, Rebecca E J; Wilkins, Sarah E; Tarhonskaya, Hanna; Flashman, Emily; Phee, Lynette M; Wareham, David W; Schofield, Christopher J.

Afiliación

Makena A; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Brem J; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Pfeffer I; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Geffen RE; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Wilkins SE; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Tarhonskaya H; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Flashman E; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Phee LM; Antimicrobial Research Group, Queen Mary University London, London E1 2AT, UK.
Wareham DW; Antimicrobial Research Group, Queen Mary University London, London E1 2AT, UK.
Schofield CJ; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK christopher.schofield@chem.ox.ac.uk.

J Antimicrob Chemother ; 70(2): 463-9, 2015 Feb.

Article en En | MEDLINE | ID: mdl-25324420

Asunto(s)

Bacterias/genética; Bacterias/metabolismo; Variación Genética; beta-Lactamasas/genética; beta-Lactamasas/metabolismo; Antibacterianos/farmacología; Bacterias/efectos de los fármacos; Clonación Molecular; Escherichia coli/efectos de los fármacos; Escherichia coli/genética; Escherichia coli/metabolismo; Humanos; Hidrólisis; Cinética; Espectrometría de Masas; Pruebas de Sensibilidad Microbiana; Modelos Moleculares; Mutagénesis Sitio-Dirigida; Plásmidos/genética; Conformación Proteica; Estabilidad Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Termodinámica; beta-Lactamasas/química

Palabras clave

antibiotic resistance; carbapenemases; cephalosporins; thermal stability; ß-lactams

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bacterias / Variación Genética / Beta-Lactamasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido

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