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Genome3D: exploiting structure to help users understand their sequences.
Lewis, Tony E; Sillitoe, Ian; Andreeva, Antonina; Blundell, Tom L; Buchan, Daniel W A; Chothia, Cyrus; Cozzetto, Domenico; Dana, José M; Filippis, Ioannis; Gough, Julian; Jones, David T; Kelley, Lawrence A; Kleywegt, Gerard J; Minneci, Federico; Mistry, Jaina; Murzin, Alexey G; Ochoa-Montaño, Bernardo; Oates, Matt E; Punta, Marco; Rackham, Owen J L; Stahlhacke, Jonathan; Sternberg, Michael J E; Velankar, Sameer; Orengo, Christine.
Afiliación
  • Lewis TE; Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK.
  • Sillitoe I; Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.
  • Andreeva A; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.
  • Blundell TL; Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.
  • Buchan DW; Department of Computer Science, UCL, Gower Street, London, WC1E 6BT, UK.
  • Chothia C; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.
  • Cozzetto D; Department of Computer Science, UCL, Gower Street, London, WC1E 6BT, UK.
  • Dana JM; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • Filippis I; Centre for Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
  • Gough J; Department of Computer Science, University of Bristol, Merchant Venturers Building, Woodland Road, Bristol, BS8 1UB, UK.
  • Jones DT; Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK Department of Computer Science, UCL, Gower Street, London, WC1E 6BT, UK.
  • Kelley LA; Centre for Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
  • Kleywegt GJ; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • Minneci F; Department of Computer Science, UCL, Gower Street, London, WC1E 6BT, UK.
  • Mistry J; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • Murzin AG; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.
  • Ochoa-Montaño B; Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.
  • Oates ME; Department of Computer Science, University of Bristol, Merchant Venturers Building, Woodland Road, Bristol, BS8 1UB, UK.
  • Punta M; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • Rackham OJ; MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
  • Stahlhacke J; Department of Computer Science, University of Bristol, Merchant Venturers Building, Woodland Road, Bristol, BS8 1UB, UK.
  • Sternberg MJ; Centre for Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
  • Velankar S; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • Orengo C; Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, London, WC1E 6BT, UK.
Nucleic Acids Res ; 43(Database issue): D382-6, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25348407
ABSTRACT
Genome3D (http//www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website to allow users to find Genome3D-annotated sequences similar to their own. We have improved and extended the Genome3D data, enlarging the source data set from three model organisms to 10, and adding VIVACE, a resource new to Genome3D. We have analysed and updated Genome3D's SCOP/CATH mapping. Finally, we have improved the superposition tools, which now give users a more powerful interface for investigating similarities and differences between structural models.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estructura Terciaria de Proteína / Bases de Datos de Proteínas / Anotación de Secuencia Molecular Tipo de estudio: Prognostic_studies Idioma: En Revista: Nucleic Acids Res Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Estructura Terciaria de Proteína / Bases de Datos de Proteínas / Anotación de Secuencia Molecular Tipo de estudio: Prognostic_studies Idioma: En Revista: Nucleic Acids Res Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido