The intron-22-inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics.

Sauna, Zuben E; Lozier, Jay N; Kasper, Carol K; Yanover, Chen; Nichols, Timothy; Howard, Tom E

Sauna, Zuben E; Lozier, Jay N; Kasper, Carol K; Yanover, Chen; Nichols, Timothy; Howard, Tom E.

Afiliación

Sauna ZE; Laboratory of Hemostasis, Division of Hematology Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD;
Lozier JN; Hematology Section, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD;
Kasper CK; Orthopaedic Hemophilia Treatment Center, Los Angeles, CA; Department of Medicine, Division of Hematology, Keck School of Medicine, University of Southern California, Los Angeles, CA;
Yanover C; Machine Learning for Healthcare and Life Sciences, IBM Research Laboratory, Haifa, Israel;
Nichols T; Department of Medicine and Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC;
Howard TE; Department of Pathology and Laboratory Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA; Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA; and Department of Patholog

Blood ; 125(2): 223-8, 2015 Jan 08.

Article en En | MEDLINE | ID: mdl-25406352

Asunto(s)

Factor VIII/inmunología; Hemofilia A/genética; Hemofilia A/inmunología; Farmacogenética; Inversión Cromosómica; Factor VIII/genética; Factor VIII/uso terapéutico; Hemofilia A/tratamiento farmacológico; Humanos; Intrones/genética; Mutación

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Farmacogenética / Factor VIII / Hemofilia A Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Blood Año: 2015 Tipo del documento: Article

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