miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
FEBS Lett
; 589(2): 246-54, 2015 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-25497012
ABSTRACT
This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enterovirus Humano B
/
MicroARNs
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Proteína de la Membrana Similar al Receptor de Coxsackie y Adenovirus
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
Hong Kong