Photoreceptor regulation of spatial visual behavior.
Invest Ophthalmol Vis Sci
; 56(3): 1842-9, 2015 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-25670495
ABSTRACT
PURPOSE:
To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.METHODS:
Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.RESULTS:
The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod-cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state.CONCLUSIONS:
The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conducta Espacial
/
Células Fotorreceptoras de Vertebrados
/
Navegación Espacial
Límite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos