MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 119(4): 459-67, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25697929
ABSTRACT
OBJECTIVES:
Oral squamous cell carcinoma (OSCC) and cutaneous squamous cell carcinoma (CSCC) are epithelial neoplasms, of which OSCC has a worse prognosis. Matrix metalloproteinases (MMPs) are involved in the initiation, invasion, metastasis, and defense of cancer. This study aimed to compare differences in MMP expression in these cancers. STUDYDESIGN:
Sixty-one patients with early-stage (T1-T2 N0 M0) cancers, of which 36 were OSCC and 25 CSCC, were enrolled into this study. Immunohistochemical staining was performed with MMP-7, MMP-8, and MMP-9 antibodies.RESULTS:
MMP-7 expression was stronger in OSCC than in CSCC, mainly in the invasive front. MMP-8 was absent and MMP-9 was mildly expressed in OSCC and CSCC cells. However, MMP-8 and MMP-9 were positive in peritumoral inflammatory cells in both cancers. In addition, MMP-7, MMP-8, and MMP-9 were not associated with the overall survival of patients with OSCC and CSCC patients.CONCLUSIONS:
The increased expression of MMP-7 in the invasive front may partly explain the aggressiveness of OSCC.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Neoplasias de la Boca
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Carcinoma de Células Escamosas
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Metaloproteinasa 9 de la Matriz
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Metaloproteinasa 8 de la Matriz
/
Metaloproteinasa 7 de la Matriz
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol
Año:
2015
Tipo del documento:
Article