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Large-scale clinical validation of a lateral flow immunoassay for detection of cryptococcal antigen in serum and cerebrospinal fluid specimens.
Suwantarat, Nuntra; Dalton, Justin B; Lee, Richard; Green, Rachel; Memon, Warda; Carroll, Karen C; Riedel, Stefan; Zhang, Sean X.
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  • Suwantarat N; Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD.
  • Dalton JB; Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD.
  • Lee R; Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, MD.
  • Green R; Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, MD.
  • Memon W; Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, MD.
  • Carroll KC; Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD; Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, MD.
  • Riedel S; Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD; The Johns Hopkins Bayview Medical Center, Baltimore, MD.
  • Zhang SX; Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD; Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, MD. Electronic address: szhang28@jhmi.edu.
Diagn Microbiol Infect Dis ; 82(1): 54-6, 2015 May.
Article en En | MEDLINE | ID: mdl-25698631
We compared a lateral flow immunoassay (LFA) to a currently used enzyme immunoassay for detection of cryptococcal antigen in 396 sera and 651 cerebrospinal fluid specimens. We found 97% concordance between the 2 assays. The LFA detected an additional 22 positives. Overall, the LFA had sensitivity of 100% and specificity of 99.6% for the diagnosis of cryptococcosis. The LFA is rapid, accurate, and easy to perform, and it is suitable for routine patient care testing.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromatografía de Afinidad / Criptococosis / Pruebas Diagnósticas de Rutina / Antígenos Fúngicos Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cromatografía de Afinidad / Criptococosis / Pruebas Diagnósticas de Rutina / Antígenos Fúngicos Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2015 Tipo del documento: Article