Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components.
J Infect Dis
; 212(5): 803-7, 2015 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-25722295
ABSTRACT
Patients with X-linked lymphoproliferative (XLP) disease due to deficiency in the adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) are highly susceptible to one specific viral pathogen, the Epstein-Barr virus (EBV). This susceptibility might result from impaired CD8(+) T-cell and natural killer cell responses to EBV infection in these patients. We demonstrate that antibody blocking of the SAP-dependent 2B4 receptor is sufficient to induce XLP-like aggravation of EBV disease in mice with reconstituted human immune system components. CD8(+) T cells require 2B4 for EBV-specific immune control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of EBV infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Antígenos CD
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Herpesvirus Humano 4
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Linfocitos T CD8-positivos
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Infecciones por Virus de Epstein-Barr
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2015
Tipo del documento:
Article