Gammaherpesviruses and canine lymphoma: no evidence for direct involvement in commonly occurring lymphomas.
J Gen Virol
; 96(Pt 7): 1863-72, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-25722346
ABSTRACT
Lymphoma is the most common haematopoietic malignancy in dogs, but little is known about the aetiology of this heterogeneous group of cancers. In humans, the Epstein-Barr virus (EBV) is associated with several lymphoma subtypes. Recently, it was suggested that EBV or an EBV-like virus is circulating in dogs. We therefore investigated whether EBV, or a novel herpesvirus, is associated with canine lymphoma using both serological and molecular techniques. In an assay designed to detect antibodies to EBV viral capsid antigens, 41 % of dogs were positive. Dogs with cancers, including lymphoma, were more frequently positive than controls, but no particular association with B-cell lymphoma was noted. EBV-specific RNA and DNA sequences were not detected in lymphoma tissue by in situ hybridization or PCR, and herpesvirus genomes were not detected using multiple degenerate PCR assays with the ability to detect novel herpesviruses. We therefore found no evidence that herpesviruses are directly involved in common types of canine lymphoma although cannot exclude the presence of an EBV-like virus in the canine population.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Gammaherpesvirinae
/
Enfermedades de los Perros
/
Linfoma
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido