In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor.
Nanomedicine (Lond)
; 10(4): 589-601, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25723092
ABSTRACT
AIM & METHODS:
The aim of the present work was to encapsulate paclitaxel (Ptx) in various lipid nanocapsules (LNCs) formulations and then to compare their pharmacokinetics and efficacy on a subcutaneous isograft model in rats.RESULTS:
Three different Ptx formulations were obtained. Drug payloads ranged from 1.32 to 3.62 mg Ptx/g of formulation. After oral administration the area under concentration-time curve was higher (p < 0.05) if Ptx was encapsulated, (1,2 Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(PEG)] (DSPE-PEG-NH2)) LNCs displaying the highest area under concentration-time curve (p < 0.05). Efficacy was better than control for standard LNCs after oral administration (p < 0.05) and for (DSPE-PEG-NH2) LNCs after intravenous administration. Despite good absorption, (DSPE-PEG-NH2) LNCs failed to remain efficient after oral route.CONCLUSION:
This study highlights the importance of efficacy studies paired to pharmacokinetic studies for nanomedicines.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfatidiletanolaminas
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Polietilenglicoles
/
Paclitaxel
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Nanocápsulas
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Glioma
/
Antineoplásicos Fitogénicos
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia