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Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.
Grabner, Beatrice; Schramek, Daniel; Mueller, Kristina M; Moll, Herwig P; Svinka, Jasmin; Hoffmann, Thomas; Bauer, Eva; Blaas, Leander; Hruschka, Natascha; Zboray, Katalin; Stiedl, Patricia; Nivarthi, Harini; Bogner, Edith; Gruber, Wolfgang; Mohr, Thomas; Zwick, Ralf Harun; Kenner, Lukas; Poli, Valeria; Aberger, Fritz; Stoiber, Dagmar; Egger, Gerda; Esterbauer, Harald; Zuber, Johannes; Moriggl, Richard; Eferl, Robert; Gyorffy, Balázs; Penninger, Josef M; Popper, Helmut; Casanova, Emilio.
Afiliación
  • Grabner B; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Schramek D; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna 1030, Austria.
  • Mueller KM; 1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna 1210 and Medical University Vienna, Vienna 1090, Austria.
  • Moll HP; Institute of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
  • Svinka J; Institute of Cancer Research &Department of Internal Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna 1090, Austria.
  • Hoffmann T; Research Institute of Molecular Pathology (IMP), Dr. Bohr Gasse 7, Vienna 1030, Austria.
  • Bauer E; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Blaas L; Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Novum, Huddinge 141 83, Sweden.
  • Hruschka N; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Zboray K; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Stiedl P; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Nivarthi H; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Bogner E; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria.
  • Gruber W; Department of Molecular Biology, Paris-Lodron University of Salzburg, Salzburg 5020, Austria.
  • Mohr T; Institute of Cancer Research &Department of Internal Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna 1090, Austria.
  • Zwick RH; Department of Internal Medicine, Karl Landsteiner University, 3430 Tulln, Austria.
  • Kenner L; 1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Clinical Institute of Pathology, Medical University of Vienna, Vienna 1090, Austria [3] Unit of Pathology of Laboratory Animals (UPLA), University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
  • Poli V; Molecular Biotechnology Center (MBC), Department of Genetics, Biology and Biochemistry, University of Turin, Turin 10126, Italy.
  • Aberger F; Department of Molecular Biology, Paris-Lodron University of Salzburg, Salzburg 5020, Austria.
  • Stoiber D; 1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Institute of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
  • Egger G; Clinical Institute of Pathology, Medical University of Vienna, Vienna 1090, Austria.
  • Esterbauer H; Department of Laboratory Medicine, Medical University of Vienna, Vienna 1090, Austria.
  • Zuber J; Research Institute of Molecular Pathology (IMP), Dr. Bohr Gasse 7, Vienna 1030, Austria.
  • Moriggl R; 1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna 1210 and Medical University Vienna, Vienna 1090, Austria.
  • Eferl R; Institute of Cancer Research &Department of Internal Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna 1090, Austria.
  • Gyorffy B; 1] MTA TTK Lendület Cancer Biomarker Research Group, Budapest 1117, Hungary [2] 2nd Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary [3] MTA-SE Pediatrics and Nephrology Research Group, Budapest 1083, Hungary.
  • Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna 1030, Austria.
  • Popper H; Institute of Pathology, Research Unit Molecular Lung and Pleura Pathology, Medical University of Graz, Graz 8036, Austria.
  • Casanova E; 1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna 1090, Austria.
Nat Commun ; 6: 6285, 2015 Mar 03.
Article en En | MEDLINE | ID: mdl-25734337
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Transducción de Señal / Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas p21(ras) / Factor de Transcripción STAT3 / Carcinogénesis / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Austria
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Transducción de Señal / Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas p21(ras) / Factor de Transcripción STAT3 / Carcinogénesis / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Austria