Surfactant-aided precipitation/on-pellet-digestion (SOD) procedure provides robust and rapid sample preparation for reproducible, accurate and sensitive LC/MS quantification of therapeutic protein in plasma and tissues.

An, Bo; Zhang, Ming; Johnson, Robert W; Qu, Jun

An, Bo; Zhang, Ming; Johnson, Robert W; Qu, Jun.

Afiliación

An B; The Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States.
Zhang M; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York 14203, United States.
Johnson RW; The Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States.
Qu J; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York 14203, United States.

Anal Chem ; 87(7): 4023-9, 2015 Apr 07.

Article en En | MEDLINE | ID: mdl-25746131

Asunto(s)

Espectrometría de Masas; Proteínas/análisis; Tensoactivos/química; Animales; Anticuerpos Monoclonales/farmacocinética; Cromatografía Liquida; Masculino; Ratas; Ratas Sprague-Dawley

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Espectrometría de Masas / Tensoactivos / Proteínas Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Anal Chem Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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