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The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Bi, Yingzhi; Dzierba, Carolyn D; Fink, Cynthia; Garcia, Yudith; Green, Michael; Han, Jianxin; Kwon, Soojin; Kumi, Godwin; Liang, Zhi; Liu, Ying; Qiao, Ying; Zhang, Yulian; Zipp, Greg; Burford, Neil; Ferrante, Meredith; Bertekap, Robert; Lewis, Martin; Cacace, Angela; Westphal, Ryan S; Kimball, David; Bronson, Joanne J; Macor, John E.
Afiliación
  • Bi Y; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Dzierba CD; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Fink C; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Garcia Y; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Green M; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Han J; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Kwon S; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Kumi G; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Liang Z; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Liu Y; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Qiao Y; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Zhang Y; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Zipp G; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Burford N; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Ferrante M; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Bertekap R; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Lewis M; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Cacace A; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Westphal RS; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Kimball D; Lexicon Pharmaceuticals, Inc., 350 Carter Road, Princeton, NJ 08540, United States.
  • Bronson JJ; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
  • Macor JE; Discovery, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, United States.
Bioorg Med Chem Lett ; 25(7): 1443-7, 2015 Apr 01.
Article en En | MEDLINE | ID: mdl-25754495
ABSTRACT
Modulating GPR88 activity is suggested to have therapeutic utility in the treatment of CNS disorders, such as schizophrenia. This Letter will describe the discovery and SAR development of a class of potent GPR88 agonists.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Receptores Acoplados a Proteínas G / Descubrimiento de Drogas / Amidas / Aminas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Central / Receptores Acoplados a Proteínas G / Descubrimiento de Drogas / Amidas / Aminas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos