Solid-state photocrosslinking of hyaluronan microfibres.
Carbohydr Polym
; 125: 153-60, 2015 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-25857970
ABSTRACT
Hyaluronan (HA) was chemically modified to a photocurable derivative by the acylation with a mixed anhydride of trans-cinnamic acid and characterized by UV, IR and 2D NMR spectroscopy. Photocurable HA was processed to a microfibrous structure by wet-spinning technology. Water solubility of otherwise water-soluble HA microfibres was reduced significantly by the solid-state photocrosslinking. We also investigated that the nature of polymer structure had a great impact to a final crosslink ratio. The analysis of the mechanical properties showed higher ultimate tensile strength and increased rigidity of the photocrosslinked fibres in comparison to the untreated ones. Moreover all tested materials are regarded as biocompatible according to the tests of cell viability, phototoxicity and enzymatic degradability, which make them suitable candidates for numerous biomedical applications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Resistencia a la Tracción
/
Reactivos de Enlaces Cruzados
/
Ácido Hialurónico
Límite:
Animals
Idioma:
En
Revista:
Carbohydr Polym
Año:
2015
Tipo del documento:
Article