[Expression of helicase DDX41 in human dental pulp tissues and cells].
Nan Fang Yi Ke Da Xue Xue Bao
; 35(4): 587-90, 2015 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-25907950
ABSTRACT
OBJECTIVE:
To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.METHODS:
The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.RESULTS:
Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.CONCLUSION:
DDX41/STING-dependent TBK1-IRF3-IFN-ß signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pulpa Dental
/
ARN Helicasas DEAD-box
/
Odontoblastos
Límite:
Humans
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2015
Tipo del documento:
Article