Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines.
Wien Med Wochenschr
; 165(11-12): 258-61, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25925225
ABSTRACT
Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Células Tumorales Cultivadas
/
Humulus
/
Flavanonas
/
Proliferación Celular
/
Fitoterapia
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Wien Med Wochenschr
Asunto de la revista:
MEDICINA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania