Pioneer translation products as an alternative source for MHC-I antigenic peptides.
Mol Immunol
; 68(2 Pt A): 68-71, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-25979818
ABSTRACT
The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsense-mediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensure that the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. The characterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Biosíntesis de Proteínas
/
Células Dendríticas
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Antígenos de Histocompatibilidad Clase I
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Empalme del ARN
/
Presentación de Antígeno
Límite:
Humans
Idioma:
En
Revista:
Mol Immunol
Año:
2015
Tipo del documento:
Article