Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.
World J Urol
; 34(1): 97-103, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-25981402
ABSTRACT
PURPOSE:
To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).METHODS:
A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.RESULTS:
Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).CONCLUSIONS:
These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Uretrales
/
Carcinoma de Células Escamosas
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Carcinoma de Células Transicionales
/
Adenocarcinoma
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
World J Urol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Alemania