Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

Makinoshima, Hideki; Takita, Masahiro; Saruwatari, Koichi; Umemura, Shigeki; Obata, Yuuki; Ishii, Genichiro; Matsumoto, Shingo; Sugiyama, Eri; Ochiai, Atsushi; Abe, Ryo; Goto, Koichi; Esumi, Hiroyasu; Tsuchihara, Katsuya

Makinoshima, Hideki; Takita, Masahiro; Saruwatari, Koichi; Umemura, Shigeki; Obata, Yuuki; Ishii, Genichiro; Matsumoto, Shingo; Sugiyama, Eri; Ochiai, Atsushi; Abe, Ryo; Goto, Koichi; Esumi, Hiroyasu; Tsuchihara, Katsuya.

Afiliación

Makinoshima H; From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, hmakinos@east.ncc.go.jp.
Takita M; From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.
Saruwatari K; the Thoracic Oncology and.
Umemura S; the Thoracic Oncology and.
Obata Y; the Divisions of Immunobiology and.
Ishii G; Pathology Divisions, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan, and.
Matsumoto S; From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Thoracic Oncology and.
Sugiyama E; the Thoracic Oncology and.
Ochiai A; Pathology Divisions, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan, and.
Abe R; the Divisions of Immunobiology and.
Goto K; the Thoracic Oncology and.
Esumi H; Clinical Research, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan.
Tsuchihara K; From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.

J Biol Chem ; 290(28): 17495-504, 2015 Jul 10.

Article en En | MEDLINE | ID: mdl-26023239

Asunto(s)

Adenocarcinoma/genética; Adenocarcinoma/metabolismo; Receptores ErbB/genética; Receptores ErbB/metabolismo; Transportador de Glucosa de Tipo 1/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Fosfatidilinositol 3-Quinasa/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; Adenocarcinoma/patología; Adenocarcinoma del Pulmón; Aerobiosis; Línea Celular Tumoral; Proliferación Celular; Genes erbB-1; Transportador de Glucosa de Tipo 1/antagonistas & inhibidores; Transportador de Glucosa de Tipo 1/genética; Glucólisis; Humanos; Ácido Láctico/metabolismo; Neoplasias Pulmonares/patología; Metabolómica; Mutación; Vía de Pentosa Fosfato; Fosforilación; Proteínas Proto-Oncogénicas c-akt/metabolismo; Interferencia de ARN; Transducción de Señal

Palabras clave

epidermal growth factor receptor (EGFR); glucose transport; glycolysis; lung cancer; mammalian target of rapamycin (mTOR); metabolomics; phosphatidylinositol 3-kinase (PI3K)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenocarcinoma / Transportador de Glucosa de Tipo 1 / Fosfatidilinositol 3-Quinasa / Serina-Treonina Quinasas TOR / Receptores ErbB / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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