Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence.

Schick, Ulrike; Kyula, Joan; Barker, Holly; Patel, Radhika; Zaidi, Shane; Gregory, Claire; Hafsi, Hind; Roulstone, Victoria; Deutsch, Eric; McLaughlin, Martin; Harrington, Kevin

Schick, Ulrike; Kyula, Joan; Barker, Holly; Patel, Radhika; Zaidi, Shane; Gregory, Claire; Hafsi, Hind; Roulstone, Victoria; Deutsch, Eric; McLaughlin, Martin; Harrington, Kevin.

Afiliación

Schick U; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Kyula J; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Barker H; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Patel R; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Zaidi S; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Gregory C; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Hafsi H; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Roulstone V; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Deutsch E; INSERM UMR 1030, Gustave Roussy, Villejuif, France.
McLaughlin M; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom.
Harrington K; Targeted Therapy Team, The Institute of Cancer Research, London, United Kingdom. Electronic address: Kevin.Harrington@icr.ac.uk.

Radiother Oncol ; 117(2): 364-75, 2015 Nov.

Article en En | MEDLINE | ID: mdl-26163092

Asunto(s)

Envejecimiento/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Melanoma Experimental/tratamiento farmacológico; Inhibidores de Proteínas Quinasas/farmacología; Piridonas/farmacología; Pirimidinonas/farmacología; Fármacos Sensibilizantes a Radiaciones/farmacología; Animales; Femenino; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Ratones; Ratones Desnudos; Mutación; Proteínas Proto-Oncogénicas B-raf/efectos de los fármacos; Proteínas ras/efectos de los fármacos

Palabras clave

GSK 1120212; MEK inhibitor; Radiosensitization; Senescence; Trametinib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridonas / Pirimidinonas / Fármacos Sensibilizantes a Radiaciones / Melanoma Experimental / Envejecimiento / Ciclo Celular / Inhibidores de Proteínas Quinasas Límite: Animals Idioma: En Revista: Radiother Oncol Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido

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