Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity.
Can J Microbiol
; 61(8): 521-30, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26182401
ABSTRACT
The metabolic interplay between hosts and viruses plays a crucial role in determining the outcome of viral infection. Viruses reorchestrate the host's primary metabolic gene networks, including genes associated with mevalonate and isoprenoid synthesis, to acquire the necessary energy and structural components for their viral life cycles. Recent work has demonstrated that the interferon-mediated antiviral response suppresses the sterol pathway through production of a signalling molecule, 25-hydroxycholesterol (25HC). This oxysterol has been shown to exert multiple effects, both through incorporation into host cellular membranes as well as through transcriptional control. Herein, we summarize our current understanding of the multifunctional roles of 25HC in the mammalian innate antiviral response.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Hidroxicolesteroles
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Can J Microbiol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá