Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.

Nata, Toshie; Basheer, Asjad; Cocchi, Fiorenza; van Besien, Richard; Massoud, Raya; Jacobson, Steven; Azimi, Nazli; Tagaya, Yutaka

Nata, Toshie; Basheer, Asjad; Cocchi, Fiorenza; van Besien, Richard; Massoud, Raya; Jacobson, Steven; Azimi, Nazli; Tagaya, Yutaka.

Afiliación

Nata T; From the Cell Biology Laboratory, Division of Basic Science, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Basheer A; BIONIZ Inc., Irvine, California 92618, and.
Cocchi F; From the Cell Biology Laboratory, Division of Basic Science, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
van Besien R; From the Cell Biology Laboratory, Division of Basic Science, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201.
Massoud R; the Section of Neuroimmunology, NINDS, National Institutes of Health, Bethesda, Maryland 20890.
Jacobson S; the Section of Neuroimmunology, NINDS, National Institutes of Health, Bethesda, Maryland 20890.
Azimi N; BIONIZ Inc., Irvine, California 92618, and.
Tagaya Y; From the Cell Biology Laboratory, Division of Basic Science, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland 21201, ytagaya@ihv.umaryland.edu.

J Biol Chem ; 290(37): 22338-51, 2015 Sep 11.

Article en En | MEDLINE | ID: mdl-26183780

Asunto(s)

Citocinas/antagonistas & inhibidores; Subunidad gamma Común de Receptores de Interleucina/antagonistas & inhibidores; Péptidos/farmacología; Células Cultivadas; Citocinas/genética; Citocinas/metabolismo; Femenino; Humanos; Subunidad gamma Común de Receptores de Interleucina/genética; Subunidad gamma Común de Receptores de Interleucina/metabolismo; Masculino; Péptidos/química; Péptidos/genética

Palabras clave

cell proliferation; cytokine action; drug design; interleukin; peptide interaction

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Péptidos / Citocinas / Subunidad gamma Común de Receptores de Interleucina Límite: Female / Humans / Male Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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