Nonstable Staphylococcus aureus Small-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization.

Leimer, Nadja; Rachmühl, Carole; Palheiros Marques, Miguel; Bahlmann, Anna Sophie; Furrer, Alexandra; Eichenseher, Fritz; Seidl, Kati; Matt, Ulrich; Loessner, Martin J; Schuepbach, Reto A; Zinkernagel, Annelies S

Leimer, Nadja; Rachmühl, Carole; Palheiros Marques, Miguel; Bahlmann, Anna Sophie; Furrer, Alexandra; Eichenseher, Fritz; Seidl, Kati; Matt, Ulrich; Loessner, Martin J; Schuepbach, Reto A; Zinkernagel, Annelies S.

Afiliación

Leimer N; Division of Infectious Diseases and Hospital Epidemiology.
Rachmühl C; Division of Infectious Diseases and Hospital Epidemiology.
Palheiros Marques M; Division of Infectious Diseases and Hospital Epidemiology.
Bahlmann AS; Division of Infectious Diseases and Hospital Epidemiology.
Furrer A; Division of Infectious Diseases and Hospital Epidemiology.
Eichenseher F; Institute of Food, Nutrition, and Health, ETH Zurich, Switzerland.
Seidl K; Division of Infectious Diseases and Hospital Epidemiology.
Matt U; Division of Infectious Diseases and Hospital Epidemiology.
Loessner MJ; Institute of Food, Nutrition, and Health, ETH Zurich, Switzerland.
Schuepbach RA; Division of Surgical Intensive Care, University Hospital Zurich, University of Zurich.
Zinkernagel AS; Division of Infectious Diseases and Hospital Epidemiology.

J Infect Dis ; 213(2): 305-13, 2016 Jan 15.

Article en En | MEDLINE | ID: mdl-26188074

Asunto(s)

Antibacterianos/farmacología; Farmacorresistencia Bacteriana/efectos de los fármacos; Fagosomas/química; Infecciones Estafilocócicas/microbiología; Staphylococcus aureus/fisiología; Cloruro de Amonio/farmacología; Animales; Línea Celular Tumoral; Cloroquina/farmacología; Regulación Bacteriana de la Expresión Génica; Variación Genética; Humanos; Concentración de Iones de Hidrógeno; Macrólidos/farmacología; Ratones; Ratones Endogámicos C57BL; Staphylococcus aureus/crecimiento & desarrollo

Palabras clave

Staphylococcus aureus; antimicrobial therapy; intracellular persistence; relapsing infections; small colony variants

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Fagosomas / Farmacorresistencia Bacteriana / Antibacterianos Límite: Animals / Humans Idioma: En Revista: J Infect Dis Año: 2016 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google