Comparative studies on sindbis virus strains isolated in Slovakia.

ABSTRACT

Two variants of Sindbis virus strains were distinguished according to the dextran sulphate (DS) marker. Large-plague strains freshly isolated from Cricetus cricetus and Rana ridibunda produced exclusively small plaques after DS treatment. The prototype Sindbis virus strain produced both large and small plaques after DS treatment. Kinetic haemagglutination-inhibition tests revealed a higher reactivity of freshly isolated strains than of the prototype strain. For differentiation of newly isolated strains of Sindbis virus, their sensitivity to sodium deoxycholate is recommended a freshly isolated strain proved to be resistant to sodium deoxycholate.