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RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect.
Zhang, Chen-Song; Liu, Qi; Li, Mengqi; Lin, Shu-Yong; Peng, Yongying; Wu, Di; Li, Terytty Yang; Fu, Qiang; Jia, Weiping; Wang, Xinjun; Ma, Teng; Zong, Yue; Cui, Jiwen; Pu, Chengfei; Lian, Guili; Guo, Huiling; Ye, Zhiyun; Lin, Sheng-Cai.
Afiliación
  • Zhang CS; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Liu Q; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Li M; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Lin SY; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Peng Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Wu D; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Li TY; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Fu Q; Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
  • Jia W; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
  • Wang X; Department of Urology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004, China.
  • Ma T; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Zong Y; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Cui J; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Pu C; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Lian G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Guo H; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Ye Z; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
  • Lin SC; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
Cell Res ; 25(9): 1025-42, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26215701
Asunto(s)
Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Proteínas de Unión al GTP rho/metabolismo; Animales; Carcinoma de Células Renales/metabolismo; Carcinoma de Células Renales/patología; Carcinoma de Células Renales/terapia; Células Cultivadas; Cobalto/farmacología; Regulación hacia Abajo/efectos de los fármacos; Células HEK293; Humanos; Hidroxilación; Prolina Dioxigenasas del Factor Inducible por Hipoxia/antagonistas & inhibidores; Prolina Dioxigenasas del Factor Inducible por Hipoxia/genética; Prolina Dioxigenasas del Factor Inducible por Hipoxia/metabolismo; Péptidos y Proteínas de Señalización Intracelular/antagonistas & inhibidores; Péptidos y Proteínas de Señalización Intracelular/genética; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Neoplasias Renales/metabolismo; Neoplasias Renales/patología; Neoplasias Renales/terapia; Proteínas con Dominio LIM/antagonistas & inhibidores; Proteínas con Dominio LIM/genética; Proteínas con Dominio LIM/metabolismo; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Noqueados; Ratones Desnudos; Unión Proteica; ARN Interferente Pequeño/metabolismo; ARN Interferente Pequeño/uso terapéutico; Trasplante Heterólogo; Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau/química; Proteína Supresora de Tumores del Síndrome de Von Hippel-Lindau/metabolismo; Proteínas de Unión al GTP rho/antagonistas & inhibidores; Proteínas de Unión al GTP rho/genética
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP rho / Complejo de la Endopetidasa Proteasomal / Subunidad alfa del Factor 1 Inducible por Hipoxia Idioma: En Revista: Cell Res Año: 2015 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP rho / Complejo de la Endopetidasa Proteasomal / Subunidad alfa del Factor 1 Inducible por Hipoxia Idioma: En Revista: Cell Res Año: 2015 Tipo del documento: Article País de afiliación: China