Changes of monocyte subsets in patients with acute coronary syndrome and correlation with myocardial injury markers.
Int J Clin Exp Pathol
; 8(6): 7266-71, 2015.
Article
en En
| MEDLINE
| ID: mdl-26261625
ABSTRACT
OBJECTIVE:
To explore the changes of peripheral blood monocytes subsets in acute coronary syndrome (ACS) and its clinical significance.METHODS:
A total of 68 ACS patients and 27 healthy subjects (HS) were enrolled. Monocyte subset analysis was performed using flow cytometry CD14++CD16-(Mon1), CD14++CD16+ (Mon2), and CD14+CD16++ (Mon3).RESULTS:
1. The number of Mon1 and Mon3 were significantly increased in ACS patients compared with HS (P<0.05) and Mon2 decreased in ACS patients (P<0.05). 2. The number of Mon1, Mon2, Mon3 was positively correlated with WBC count (P<0.05). The Mon2% was negatively correlated with the serum levels of LDH, CK, CK-MB (P<0.05). The number of Mon1, Mon3 was positively correlated with the serum levels of LDH, CK, CK-MB (P<0.05).CONCLUSION:
The changes in different subsets of monocytes may be associated with pathogenesis of ACS and myocardial injury. The findings might be useful in the assessment of myocardial injury.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Monocitos
/
Síndrome Coronario Agudo
/
Miocardio
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Clin Exp Pathol
Asunto de la revista:
PATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China