Formation of sulfur adducts of N-acetyl-p-benzoquinoneimine, an electrophilic metabolite of acetaminophen in vivo: participation of reactive persulfides.

Abiko, Yumi; Ishii, Isao; Kamata, Shotaro; Tsuchiya, Yukihiro; Watanabe, Yasuo; Ihara, Hideshi; Akaike, Takaaki; Kumagai, Yoshito

Abiko, Yumi; Ishii, Isao; Kamata, Shotaro; Tsuchiya, Yukihiro; Watanabe, Yasuo; Ihara, Hideshi; Akaike, Takaaki; Kumagai, Yoshito.

Afiliación

Abiko Y; Environmental Biology Section, Faculty of Medicine, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Ishii I; Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences , Tokyo 105-8512, Japan.
Kamata S; Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences , Tokyo 105-8512, Japan.
Tsuchiya Y; Laboratory of Pharmacology, Showa Pharmaceutical University , Tokyo 194-8543, Japan.
Watanabe Y; Laboratory of Pharmacology, Showa Pharmaceutical University , Tokyo 194-8543, Japan.
Ihara H; Department of Biological Science, Graduate School of Science, Osaka Prefecture University , Osaka 599-8531, Japan.
Akaike T; Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine , Sendai 980-8575, Japan.
Kumagai Y; Environmental Biology Section, Faculty of Medicine, University of Tsukuba , 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Chem Res Toxicol ; 28(9): 1796-802, 2015 Sep 21.

Article en En | MEDLINE | ID: mdl-26304691

Asunto(s)

Acetaminofén/química; Benzoquinonas/química; Iminas/química; Sulfuros/química; Azufre/química; Animales; Cromatografía Liquida; Ratones; Ratones Endogámicos C57BL; Espectrometría de Masas en Tándem

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sulfuros / Azufre / Benzoquinonas / Iminas / Acetaminofén Límite: Animals Idioma: En Revista: Chem Res Toxicol Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google