Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2.

Lu, Chunfeng; Jiang, Yuanyuan; Zhang, Feng; Shao, Jiangjuan; Wu, Li; Wu, Xiafei; Lian, Naqi; Chen, Lianyun; Jin, Huanhuan; Chen, Qin; Lu, Yin; Zheng, Shizhong

Lu, Chunfeng; Jiang, Yuanyuan; Zhang, Feng; Shao, Jiangjuan; Wu, Li; Wu, Xiafei; Lian, Naqi; Chen, Lianyun; Jin, Huanhuan; Chen, Qin; Lu, Yin; Zheng, Shizhong.

Afiliación

Lu C; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Jiang Y; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zhang F; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Shao J; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Wu L; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Wu X; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Lian N; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Chen L; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Jin H; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Chen Q; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Lu Y; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
Zheng S; Department of Pharmacology, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China. Electronic addr

Life Sci ; 141: 119-27, 2015 Nov 15.

Article en En | MEDLINE | ID: mdl-26341692

Asunto(s)

Antioxidantes/farmacología; Depresores del Sistema Nervioso Central/antagonistas & inhibidores; Depresores del Sistema Nervioso Central/toxicidad; Etanol/antagonistas & inhibidores; Etanol/toxicidad; Hepatocitos/efectos de los fármacos; Factor 2 Relacionado con NF-E2/metabolismo; Pirazinas/farmacología; Alanina Transaminasa/metabolismo; Apoptosis/efectos de los fármacos; Aspartato Aminotransferasas/metabolismo; Biomarcadores; Células Cultivadas; Humanos; Metabolismo de los Lípidos/efectos de los fármacos; Factor 2 Relacionado con NF-E2/genética; Estrés Oxidativo/efectos de los fármacos; Plásmidos/genética; ARN Interferente Pequeño/farmacología; Superóxido Dismutasa/metabolismo

Palabras clave

Alcoholic liver disease; Hepatocyte; Lipid accumulation; Oxidative stress

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Depresores del Sistema Nervioso Central / Hepatocitos / Etanol / Factor 2 Relacionado con NF-E2 / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Life Sci Año: 2015 Tipo del documento: Article País de afiliación: China

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