Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities.

Lu, Juan; Sun, Qin; Tu, Zheng-Chao; Lv, Qing; Shui, Pi-Xian; Cheng, Yong-Xian

Lu, Juan; Sun, Qin; Tu, Zheng-Chao; Lv, Qing; Shui, Pi-Xian; Cheng, Yong-Xian.

Afiliación

Lu J; School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. lvqing@mail.kib.ac.cn.
Sun Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China. lvqing@mail.kib.ac.cn.
Tu ZC; School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. sdy-0502@126.com.
Lv Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, China. tu_zhengchao@gibh.ac.cn.
Shui PX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, China. lvqing@mail.kib.ac.cn.
Cheng YX; School of Medicine, Sichuan Medical University, 319 Zhongshan Road, Luzhou 646000, China. spx6702@163.com.

Molecules ; 20(9): 15589-96, 2015 Aug 27.

Article en En | MEDLINE | ID: mdl-26343619

ABSTRACT

ABSTRACT

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.

Asunto(s)

Escarabajos/metabolismo; Ciclooxigenasa 1/metabolismo; Ciclooxigenasa 2/metabolismo; Dopamina/análogos & derivados; Inhibidores Enzimáticos/farmacología; Animales; Línea Celular; Escarabajos/química; Perros; Dopamina/química; Dopamina/farmacología; Células HeLa; Humanos; Proteínas de Insectos/química; Proteínas de Insectos/farmacología; Células MCF-7; Células de Riñón Canino Madin Darby; Estructura Molecular

Palabras clave

COX-1; COX-2; Catharsius molossus; N-acetyldopamine dimers

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Escarabajos / Dopamina / Inhibidores Enzimáticos / Ciclooxigenasa 1 / Ciclooxigenasa 2 Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: China

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