NK-cells are involved in thymic atrophy induced by influenza A virus infection.
J Gen Virol
; 96(11): 3223-3235, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26346306
ABSTRACT
NK-cells have traditionally been viewed as innate effector lymphocytes that serve as a first line of defence against a range of viruses and tumours. More recently, the importance of NK-cell immunoregulatory functions has been highlighted. NK-cells can inhibit antiviral T-cell responses, and also play an important role in controlling harmful T-cell activity in autoimmunity and transplantation settings. Moreover, immunopathological effects of NK-cells during infection have been reported. Nevertheless, the phenotype and function of NK-cells in the thymus during influenza virus infection is not understood. In the present study, we demonstrated that influenza A virus (IAV) infection in mice led to severe thymic atrophy caused by increased thymic T-cell apoptosis and suppressed proliferation. We found that NK-cells played a critical role in this phenotype. IFN-c production by NK-cells was a contributing factor for thymic atrophy during IAV infection. Taken together, our data indicate that NK-cells are involved in the thymic atrophy associated with IAV infection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timo
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Células Asesinas Naturales
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Gripe Humana
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Subtipo H1N1 del Virus de la Influenza A
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
J Gen Virol
Año:
2015
Tipo del documento:
Article