Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra, Aleksandra A; Mullen, Peter J; Goard, Carolyn A; Ericson, Elke; Sharma, Piyush; Kalkat, Manpreet; Yu, Rosemary; Pong, Janice T; Brown, Kevin R; Hart, Traver; Gebbia, Marinella; Lang, Karl S; Giaever, Guri; Nislow, Corey; Moffat, Jason; Penn, Linda Z

Pandyra, Aleksandra A; Mullen, Peter J; Goard, Carolyn A; Ericson, Elke; Sharma, Piyush; Kalkat, Manpreet; Yu, Rosemary; Pong, Janice T; Brown, Kevin R; Hart, Traver; Gebbia, Marinella; Lang, Karl S; Giaever, Guri; Nislow, Corey; Moffat, Jason; Penn, Linda Z.

Afiliación

Pandyra AA; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Mullen PJ; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Goard CA; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Ericson E; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Sharma P; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Kalkat M; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Yu R; Donnelly Centre and Banting & Best Department of Medical Research, University of Toronto, Toronto, ON, Canada.
Pong JT; Now located at AstraZeneca R&D, Mölndal, Sweden.
Brown KR; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Hart T; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Gebbia M; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Lang KS; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Giaever G; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Nislow C; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Moffat J; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Penn LZ; Donnelly Centre and Banting & Best Department of Medical Research, University of Toronto, Toronto, ON, Canada.

Oncotarget ; 6(29): 26909-21, 2015 Sep 29.

Article en En | MEDLINE | ID: mdl-26353928

Asunto(s)

Apoptosis; Regulación Neoplásica de la Expresión Génica; Ácido Mevalónico/metabolismo; Neoplasias/patología; Interferencia de ARN; Antineoplásicos/química; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/metabolismo; Línea Celular Tumoral; Proliferación Celular; Dimetilaliltranstransferasa/genética; Farnesiltransferasa/genética; Ácidos Grasos Monoinsaturados/química; Femenino; Fluvastatina; Geraniltranstransferasa/genética; Humanos; Hidroximetilglutaril-CoA Reductasas/metabolismo; Hidroximetilglutaril-CoA Sintasa/genética; Indoles/química; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/metabolismo; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Neoplasias/metabolismo; ARN Interferente Pequeño/metabolismo; Reacción en Cadena en Tiempo Real de la Polimerasa; Proteína 2 de Unión a Elementos Reguladores de Esteroles/genética

Palabras clave

SREBP2; feedback inhibition; mevalonate pathway; statins; tumor metabolism

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Apoptosis / Interferencia de ARN / Ácido Mevalónico / Neoplasias Límite: Female / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Canadá

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