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VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Gebremariam, Teclegiorgis; Wiederhold, Nathan P; Fothergill, Annette W; Garvey, Edward P; Hoekstra, William J; Schotzinger, Robert J; Patterson, Thomas F; Filler, Scott G; Ibrahim, Ashraf S.
Afiliación
  • Gebremariam T; The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
  • Wiederhold NP; University of Texas Health Sciences at San Antonio, San Antonio, Texas, USA.
  • Fothergill AW; University of Texas Health Sciences at San Antonio, San Antonio, Texas, USA.
  • Garvey EP; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Hoekstra WJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Schotzinger RJ; Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
  • Patterson TF; University of Texas Health Sciences at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
  • Filler SG; The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Ibrahim AS; The Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA David Geffen School of Medicine at UCLA, Los Angeles, California, USA ibrahim@l
Antimicrob Agents Chemother ; 59(12): 7815-7, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26369977
ABSTRACT
We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Rhizopus / Tetrazoles / Huésped Inmunocomprometido / Mucormicosis / Antifúngicos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Rhizopus / Tetrazoles / Huésped Inmunocomprometido / Mucormicosis / Antifúngicos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos