VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Antimicrob Agents Chemother
; 59(12): 7815-7, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26369977
ABSTRACT
We studied the efficacy of the investigational drug VT-1161 against mucormycosis. VT-1161 had more potent in vitro activity against Rhizopus arrhizus var. arrhizus than against R. arrhizus var. delemar. VT-1161 treatment demonstrated dose-dependent plasma drug levels with prolonged survival time and lowered tissue fungal burden in immunosuppressed mice infected with R. arrhizus var. arrhizus and was as effective as high-dose liposomal amphotericin B treatment. These results support further development of VT-1161 against mucormycosis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Rhizopus
/
Tetrazoles
/
Huésped Inmunocomprometido
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Mucormicosis
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos