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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Kato, Norihiro; Loh, Marie; Takeuchi, Fumihiko; Verweij, Niek; Wang, Xu; Zhang, Weihua; Kelly, Tanika N; Saleheen, Danish; Lehne, Benjamin; Leach, Irene Mateo; Drong, Alexander W; Abbott, James; Wahl, Simone; Tan, Sian-Tsung; Scott, William R; Campanella, Gianluca; Chadeau-Hyam, Marc; Afzal, Uzma; Ahluwalia, Tarunveer S; Bonder, Marc Jan; Chen, Peng; Dehghan, Abbas; Edwards, Todd L; Esko, Tõnu; Go, Min Jin; Harris, Sarah E; Hartiala, Jaana; Kasela, Silva; Kasturiratne, Anuradhani; Khor, Chiea-Chuen; Kleber, Marcus E; Li, Huaixing; Yu Mok, Zuan; Nakatochi, Masahiro; Sapari, Nur Sabrina; Saxena, Richa; Stewart, Alexandre F R; Stolk, Lisette; Tabara, Yasuharu; Teh, Ai Ling; Wu, Ying; Wu, Jer-Yuarn; Zhang, Yi; Aits, Imke; Da Silva Couto Alves, Alexessander; Das, Shikta; Dorajoo, Rajkumar; Hopewell, Jemma C; Kim, Yun Kyoung; Koivula, Robert W.
Afiliación
  • Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Loh M; Institute of Health Sciences, University of Oulu, Oulu, Finland.
  • Takeuchi F; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Verweij N; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore.
  • Wang X; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • Zhang W; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Kelly TN; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Saleheen D; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Lehne B; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
  • Leach IM; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
  • Drong AW; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Abbott J; Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
  • Wahl S; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Tan ST; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Scott WR; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Campanella G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Chadeau-Hyam M; Bioinformatics Support Service, Imperial College London, London, UK.
  • Afzal U; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Ahluwalia TS; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Bonder MJ; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Chen P; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
  • Dehghan A; National Heart and Lung Institute, Imperial College London, London, UK.
  • Edwards TL; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Esko T; National Heart and Lung Institute, Imperial College London, London, UK.
  • Go MJ; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Harris SE; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Hartiala J; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Kasela S; Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK.
  • Kasturiratne A; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Khor CC; Copenhagen Prospective Studies on Asthma in Childhood (COSPAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Kleber ME; Steno Diabetes Center, Gentofte, Denmark.
  • Li H; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Yu Mok Z; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Nakatochi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Sapari NS; Vanderbilt Epidemiology Center, Center for Human Genetics Research, Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
  • Saxena R; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Stewart AFR; Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA.
  • Stolk L; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • Tabara Y; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • Teh AL; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
  • Wu Y; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and Medical Research Council (MRC) Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
  • Wu JY; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Zhang Y; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Aits I; Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
  • Da Silva Couto Alves A; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Das S; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
  • Dorajoo R; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
  • Hopewell JC; Genome Institute of Singapore, ASTAR, Singapore.
  • Kim YK; Department of Ophthalmology, National University of Singapore, Singapore.
  • Koivula RW; Department of Paediatrics, National University of Singapore, Singapore.
Nat Genet ; 47(11): 1282-1293, 2015 11.
Article en En | MEDLINE | ID: mdl-26390057
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Metilación de ADN / Estudio de Asociación del Genoma Completo / Sitios Genéticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Metilación de ADN / Estudio de Asociación del Genoma Completo / Sitios Genéticos Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Japón