Self-organization of "fibro-axonal" composite tissue around unmodified metallic micro-electrodes can form a functioning interface with a peripheral nerve: A new direction for creating long-term neural interfaces.
Muscle Nerve
; 53(5): 789-96, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-26425938
ABSTRACT
INTRODUCTION:
A long-term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material.METHODS:
We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks.RESULTS:
Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro-collagenous tissue, forming a physical interface with the tungsten micro-electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99 ± 2.46 and 20.14 ± 4 m/s.CONCLUSIONS:
We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Nervio Ciático
/
Axones
/
Potenciales de Acción
/
Electrodos Implantados
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Microelectrodos
/
Tejido Nervioso
/
Conducción Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2016
Tipo del documento:
Article
País de afiliación:
Singapur