Synthesis of Substituted Tropones by Sequential Rh-Catalyzed [5+2] Cycloaddition and Elimination.

Song, Wangze; Xi, Bao-Min; Yang, Ka; Tang, Weiping

Song, Wangze; Xi, Bao-Min; Yang, Ka; Tang, Weiping.

Afiliación

Song W; School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA.
Xi BM; School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, P. R. China.
Yang K; School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA.
Tang W; School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705-2222, USA ; Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA.

Tetrahedron ; 71(35): 5979-5984, 2015 Sep 02.

Article en En | MEDLINE | ID: mdl-26456984

ABSTRACT

ABSTRACT

Highly substituted tropones are prepared from cycloheptatrienes derived from Rh-catalyzed intermolecular [5+2] cycloaddition of 3-acyloxy-1,4-enynes and propargylic alcohols. The intermolecular [5+2] cycloaddition is highly regioselective for a variety of propargylic alcohols. Elimination of the cycloaddition products afforded various substituted tropones.

Palabras clave

1,4-enynes; alkynes; cycloaddition; rhodium; tropone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Tetrahedron Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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