Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.
J Physiol Sci
; 66(2): 175-88, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26507418
ABSTRACT
Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca(2+) and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Vasos Sanguíneos
/
Transducción de Señal
/
Canales Iónicos
/
Sistema Nervioso
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Physiol Sci
Asunto de la revista:
FISIOLOGIA
/
TRAUMATOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón