NF-&#954;B contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.

Nguyen, Chi Huu; Senfter, Daniel; Basilio, Jose; Holzner, Silvio; Stadler, Serena; Krieger, Sigurd; Huttary, Nicole; Milovanovic, Daniela; Viola, Katharina; Simonitsch-Klupp, Ingrid; Jäger, Walter; de Martin, Rainer; Krupitza, Georg

NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.

Nguyen, Chi Huu; Senfter, Daniel; Basilio, Jose; Holzner, Silvio; Stadler, Serena; Krieger, Sigurd; Huttary, Nicole; Milovanovic, Daniela; Viola, Katharina; Simonitsch-Klupp, Ingrid; Jäger, Walter; de Martin, Rainer; Krupitza, Georg.

Afiliación

Nguyen CH; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.
Senfter D; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Basilio J; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Holzner S; Department of Vascular Biology and Thrombosis Research, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria.
Stadler S; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Krieger S; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Huttary N; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Milovanovic D; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Viola K; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Simonitsch-Klupp I; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
Jäger W; Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
de Martin R; Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.
Krupitza G; Department of Vascular Biology and Thrombosis Research, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria.

Oncotarget ; 6(36): 39262-75, 2015 Nov 17.

Article en En | MEDLINE | ID: mdl-26513020

Asunto(s)

Neoplasias de la Mama/metabolismo; Células Endoteliales/metabolismo; Metaloproteinasa 1 de la Matriz/biosíntesis; FN-kappa B/metabolismo; Receptor PAR-1/metabolismo; Proteínas de Arabidopsis; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Línea Celular Tumoral; Movimiento Celular/fisiología; Femenino; Humanos; Células MCF-7; Metaloproteinasa 1 de la Matriz/genética; Metaloproteinasa 1 de la Matriz/metabolismo; Comunicación Paracrina; Receptor PAR-1/genética; Esferoides Celulares; Transfección

Palabras clave

MMP1; NFKB1; PAR1; RELA; lymph endothelial cell migration

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / FN-kappa B / Metaloproteinasa 1 de la Matriz / Células Endoteliales / Receptor PAR-1 Límite: Female / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Austria

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