High-Throughput Melanin-Binding Affinity and In Silico Methods to Aid in the Prediction of Drug Exposure in Ocular Tissue.

Reilly, John; Williams, Sarah L; Forster, Cornelia J; Kansara, Viral; End, Peter; Serrano-Wu, Michael H

Reilly, John; Williams, Sarah L; Forster, Cornelia J; Kansara, Viral; End, Peter; Serrano-Wu, Michael H.

Afiliación

Reilly J; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Cambridge, Massachusetts 02139. Electronic address: john.reilly@novartis.com.
Williams SL; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Cambridge, Massachusetts 02139.
Forster CJ; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Cambridge, Massachusetts 02139.
Kansara V; Novartis Institutes for BioMedical Research, Ophthalmology, Cambridge, Massachusetts 02139.
End P; Novartis Institutes for BioMedical Research, DMPK, Basel, Switzerland.
Serrano-Wu MH; Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Cambridge, Massachusetts 02139.

J Pharm Sci ; 104(12): 3997-4001, 2015 Dec.

Article en En | MEDLINE | ID: mdl-26524700

Asunto(s)

Ojo/metabolismo; Melaninas/metabolismo; Preparaciones Farmacéuticas/metabolismo; Simulación por Computador; Relación Estructura-Actividad Cuantitativa

Palabras clave

QSAR; affinity chromatography; bioanalysis; in-vitro-in-vivo correlation (IVIVC); distribution; in silico; ocular PK; melanin; modeling; pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Ojo / Melaninas Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Pharm Sci Año: 2015 Tipo del documento: Article

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