Dysregulation of the Keap1-Nrf2 pathway in cancer.
Biochem Soc Trans
; 43(4): 645-9, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26551706
ABSTRACT
Accumulating evidence suggests that dysregulation of the Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2) pathway resulting in constitutively active Nrf2 and increased expression of cytoprotective Nrf2 target genes, has a pivotal role in cancer. Cancer cells are able to hijack the Keap1-Nrf2 system via multiple mechanisms leading to enhanced chemo- and radio-resistance and proliferation via metabolic reprogramming as well as inhibition of apoptosis. In this mini-review, we will describe the mechanisms leading to increased Nrf2 activity in cancer with a focus on the information achieved from large-scale multi-omics projects across various cancer types.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Péptidos y Proteínas de Señalización Intracelular
/
Factor 2 Relacionado con NF-E2
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2015
Tipo del documento:
Article
País de afiliación:
Finlandia