The association of factor V leiden mutation with recurrent pregnancy loss.
J Pak Med Assoc
; 65(11): 1169-72, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26564286
ABSTRACT
OBJECTIVE:
To determine the association of factor V Leiden mutation with recurrent pregnancy loss.METHODS:
The case-control study was conducted at the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from January to June 2012, and comprised women of 18 to 45 years of age who had a history of recurrent pregnancy loss, and controls with no history of pregnancy loss. All the subjects belonged to Punjabi ethnic group. Three ml blood was taken from cases and controls and deoxyribonucleic acid was extracted. In order to identify Factor V Leiden mutation, polymerase chain reaction method was utilised combined with the amplification refractory mutation system. Data was analysed using SPSS 17.RESULTS:
Of the 112 subjects, 56(50%) were in each of the two groups. The presence of factor V Leiden mutation among the cases was 3(5.4%) while it was absent among the controls. The mutation was significantly associated with recurrent pregnancy loss (p=0.017).Recurrent pregnancy loss was higher in cases than controls (p=0.001).CONCLUSIONS:
Factor V Leiden mutation, Recurrent pregnancy loss, PCR (Polymerase chain reaction).Palabras clave
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor V
/
Aborto Habitual
/
Trombofilia
/
Mutación
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Pak Med Assoc
Año:
2015
Tipo del documento:
Article