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A Common Mechanism that Underpins Antibody Diversification.
Murre, Cornelis.
Afiliación
  • Murre C; Department of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: cmurre@ucsd.edu.
Cell ; 163(5): 1055-1056, 2015 Nov 19.
Article en En | MEDLINE | ID: mdl-26590414
ABSTRACT
Targeting of AID to antibody variable (V) regions results in somatic hypermutation, whereas its recruitment to switch (S) regions leads to class-switch recombination. Yeap et al. find that the mechanism by which variable and switch regions recruit AID essentially is the same but that the two regions differ in the density of double-stranded DNA breaks that are generated. These lead to either point mutations in V exons in somatic hypermutation or deletion of intervening DNA sequences during class switch recombination.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos B / Cambio de Clase de Inmunoglobulina / Citidina Desaminasa / Hipermutación Somática de Inmunoglobulina / Recombinación V(D)J Límite: Animals / Humans Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos B / Cambio de Clase de Inmunoglobulina / Citidina Desaminasa / Hipermutación Somática de Inmunoglobulina / Recombinación V(D)J Límite: Animals / Humans Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article