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PART of the WHOLE: A Case Study in Wellness-Oriented Personalized Medicine.
Gibson, Greg; Marigorta, Urko M; Ojagbeghru, Elohor R; Park, Subin.
Afiliación
  • Gibson G; School of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
  • Marigorta UM; School of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
  • Ojagbeghru ER; School of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
  • Park S; School of Biology, Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, Georgia.
Yale J Biol Med ; 88(4): 397-406, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26604864
We describe the Wellness and Health Omics Linked to the Environment (WHOLE) personalized medicine profile for a 50-year-old Caucasian male living in Atlanta, Georgia. Based on the principle that genomic medicine will be most effective when presented in the context of an individual's clinical and lifestyle data, we propose the use of a "risk radar" that summarizes health risks in eight domains. Rather than providing overwhelming lists of potentially deleterious genetic variants, we argue that profiles should be palatable, actionable, reproducible, and teachable: the PART principle. Genetic risk scores for this individual are strikingly concordant for his height, body mass index (BMI), waist hip ration (WHR), and cholesterol, and blood transcriptome data agrees with and complements his complete blood counts. Despite enjoying currently good health, his risk radar highlights metabolic disease as his major health concern.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicina de Precisión / Promoción de la Salud Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Yale J Biol Med Año: 2015 Tipo del documento: Article País de afiliación: Georgia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicina de Precisión / Promoción de la Salud Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Yale J Biol Med Año: 2015 Tipo del documento: Article País de afiliación: Georgia