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Identification of an allosteric binding site for RORγt inhibition.
Scheepstra, Marcel; Leysen, Seppe; van Almen, Geert C; Miller, J Richard; Piesvaux, Jennifer; Kutilek, Victoria; van Eenennaam, Hans; Zhang, Hongjun; Barr, Kenneth; Nagpal, Sunil; Soisson, Stephen M; Kornienko, Maria; Wiley, Kristen; Elsen, Nathaniel; Sharma, Sujata; Correll, Craig C; Trotter, B Wesley; van der Stelt, Mario; Oubrie, Arthur; Ottmann, Christian; Parthasarathy, Gopal; Brunsveld, Luc.
Afiliación
  • Scheepstra M; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600MB, The Netherlands.
  • Leysen S; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600MB, The Netherlands.
  • van Almen GC; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600MB, The Netherlands.
  • Miller JR; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Piesvaux J; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Kutilek V; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • van Eenennaam H; Merck Research Laboratories, Molenstraat 110, Oss 5342 CC, The Netherlands.
  • Zhang H; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Barr K; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Nagpal S; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Soisson SM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, Pennsylvania 19486, USA.
  • Kornienko M; Merck Research Laboratories, 503 Louise Lane, North Wales, Pennsylvania 19454, USA.
  • Wiley K; Merck Research Laboratories, 503 Louise Lane, North Wales, Pennsylvania 19454, USA.
  • Elsen N; Merck Research Laboratories, 503 Louise Lane, North Wales, Pennsylvania 19454, USA.
  • Sharma S; Merck Research Laboratories, 503 Louise Lane, North Wales, Pennsylvania 19454, USA.
  • Correll CC; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • Trotter BW; Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
  • van der Stelt M; Merck Research Laboratories, Molenstraat 110, Oss 5342 CC, The Netherlands.
  • Oubrie A; Merck Research Laboratories, Molenstraat 110, Oss 5342 CC, The Netherlands.
  • Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600MB, The Netherlands.
  • Parthasarathy G; Merck Research Laboratories, 770 Sumneytown Pike, West Point, Pennsylvania 19486, USA.
  • Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, Eindhoven 5600MB, The Netherlands.
Nat Commun ; 6: 8833, 2015 Dec 07.
Article en En | MEDLINE | ID: mdl-26640126
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-17 / Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interleucina-17 / Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos