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Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Blanco, Maria-Jesus; Vetman, Tatiana; Chandrasekhar, Srinivasan; Fisher, Matthew J; Harvey, Anita; Chambers, Mark; Lin, Chaohua; Mudra, Daniel; Oskins, Jennifer; Wang, Xu-Shan; Yu, Xiao-Peng; Warshawsky, Alan M.
Afiliación
  • Blanco MJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States. Electronic address: blanco_maria@lilly.com.
  • Vetman T; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Chandrasekhar S; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Fisher MJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Harvey A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Chambers M; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Lin C; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Mudra D; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Oskins J; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Wang XS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Yu XP; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
  • Warshawsky AM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, United States.
Bioorg Med Chem Lett ; 26(3): 931-935, 2016 Feb 01.
Article en En | MEDLINE | ID: mdl-26764191
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Picolinas / Ácido Benzoico / Subtipo EP4 de Receptores de Prostaglandina E Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Picolinas / Ácido Benzoico / Subtipo EP4 de Receptores de Prostaglandina E Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article