Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma.

Grohar, Patrick J; Kim, Suntae; Rangel Rivera, Guillermo O; Sen, Nirmalya; Haddock, Sara; Harlow, Matt L; Maloney, Nichole K; Zhu, Jack; O'Neill, Maura; Jones, Tamara L; Huppi, Konrad; Grandin, Magdalena; Gehlhaus, Kristen; Klumpp-Thomas, Carleen A; Buehler, Eugen; Helman, Lee J; Martin, Scott E; Caplen, Natasha J

Grohar, Patrick J; Kim, Suntae; Rangel Rivera, Guillermo O; Sen, Nirmalya; Haddock, Sara; Harlow, Matt L; Maloney, Nichole K; Zhu, Jack; O'Neill, Maura; Jones, Tamara L; Huppi, Konrad; Grandin, Magdalena; Gehlhaus, Kristen; Klumpp-Thomas, Carleen A; Buehler, Eugen; Helman, Lee J; Martin, Scott E; Caplen, Natasha J.

Afiliación

Grohar PJ; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Kim S; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Rangel Rivera GO; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; NIH Academy, Office of Intramural Training and Education, NIH, Bethesda, MD 20892, USA.
Sen N; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Haddock S; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Harlow ML; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Maloney NK; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Zhu J; Molecular Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
O'Neill M; Protein Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jones TL; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Huppi K; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Grandin M; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Gehlhaus K; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Klumpp-Thomas CA; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
Buehler E; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
Helman LJ; Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Martin SE; Trans-NIH RNAi Screening Facility, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.
Caplen NJ; Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: ncaplen@mail.nih.gov.

Cell Rep ; 14(3): 598-610, 2016 Jan 26.

Article en En | MEDLINE | ID: mdl-26776507

Asunto(s)

Proteínas de Fusión Oncogénica/metabolismo; Proteína Proto-Oncogénica c-fli-1/metabolismo; Proteína EWS de Unión a ARN/metabolismo; Secuencia de Bases; Sitios de Unión; Proteínas de Unión a Calmodulina/antagonistas & inhibidores; Proteínas de Unión a Calmodulina/genética; Proteínas de Unión a Calmodulina/metabolismo; Línea Celular Tumoral; Supervivencia Celular; Exones; Regulación Neoplásica de la Expresión Génica; Ribonucleoproteína Heterogénea-Nuclear Grupo F-H/antagonistas & inhibidores; Ribonucleoproteína Heterogénea-Nuclear Grupo F-H/genética; Ribonucleoproteína Heterogénea-Nuclear Grupo F-H/metabolismo; Humanos; Proteínas de Microfilamentos/antagonistas & inhibidores; Proteínas de Microfilamentos/genética; Proteínas de Microfilamentos/metabolismo; Proteínas de Fusión Oncogénica/antagonistas & inhibidores; Proteínas de Fusión Oncogénica/genética; Fosfoproteínas/antagonistas & inhibidores; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Proteína Proto-Oncogénica c-fli-1/antagonistas & inhibidores; Proteína Proto-Oncogénica c-fli-1/genética; Interferencia de ARN; Precursores del ARN/metabolismo; Empalme del ARN; Factores de Empalme de ARN; ARN Interferente Pequeño/metabolismo; Proteína EWS de Unión a ARN/antagonistas & inhibidores; Proteína EWS de Unión a ARN/genética; Proteínas de Unión al ARN/antagonistas & inhibidores; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Receptores Citoplasmáticos y Nucleares/antagonistas & inhibidores; Receptores Citoplasmáticos y Nucleares/genética; Receptores Citoplasmáticos y Nucleares/metabolismo; Ribonucleoproteína Nuclear Pequeña U2/antagonistas & inhibidores; Ribonucleoproteína Nuclear Pequeña U2/genética; Ribonucleoproteína Nuclear Pequeña U2/metabolismo; Sarcoma de Ewing/patología; Transactivadores; Factores de Transcripción/antagonistas & inhibidores; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Fusión Oncogénica / Proteína EWS de Unión a ARN / Proteína Proto-Oncogénica c-fli-1 Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Cell Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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