Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity.
Biochem Biophys Res Commun
; 470(1): 213-219, 2016 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-26778001
ABSTRACT
Function of cellular prion protein (PrP(c)) in cancer progression has not been elucidated yet. Ectopic expression of PrP(c) increases the invasion and migration of breast cancer cell line, MCF-7 cells. Overexpressed PrP(c) increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-κB in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrP(c) by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrP(c) contribute the breast cancer invasion and migration via MMP-9.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
FN-kappa B
/
Proteínas PrPC
/
Metaloproteinasa 9 de la Matriz
/
Sistema de Señalización de MAP Quinasas
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2016
Tipo del documento:
Article
País de afiliación:
Corea del Sur