Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model.

Moore, John H; van Opstal, Edward; Kolling, Glynis L; Shin, Jae Hyun; Bogatcheva, Elena; Nikonenko, Boris; Einck, Leo; Phipps, Andrew J; Guerrant, Richard L; Protopopova, Marina; Warren, Cirle Alcantara

Moore, John H; van Opstal, Edward; Kolling, Glynis L; Shin, Jae Hyun; Bogatcheva, Elena; Nikonenko, Boris; Einck, Leo; Phipps, Andrew J; Guerrant, Richard L; Protopopova, Marina; Warren, Cirle Alcantara.

Afiliación

Moore JH; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
van Opstal E; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
Kolling GL; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
Shin JH; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
Bogatcheva E; Sequella Inc., Rockville, MD 20850, USA.
Nikonenko B; Sequella Inc., Rockville, MD 20850, USA.
Einck L; Sequella Inc., Rockville, MD 20850, USA.
Phipps AJ; Sequella Inc., Rockville, MD 20850, USA.
Guerrant RL; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.
Protopopova M; Sequella Inc., Rockville, MD 20850, USA.
Warren CA; Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA ca6t@virginia.edu.

J Antimicrob Chemother ; 71(5): 1300-6, 2016 May.

Article en En | MEDLINE | ID: mdl-26832756

Asunto(s)

Aminoglicósidos/uso terapéutico; Antibacterianos/uso terapéutico; Clostridioides difficile/efectos de los fármacos; Enterocolitis Seudomembranosa/tratamiento farmacológico; Uridina/análogos & derivados; Administración Oral; Animales; Derrame de Bacterias; Toxinas Bacterianas/análisis; Modelos Animales de Enfermedad; Enterocolitis Seudomembranosa/microbiología; Enterocolitis Seudomembranosa/patología; Heces/química; Heces/microbiología; Masculino; Ratones Endogámicos C57BL; Índice de Severidad de la Enfermedad; Análisis de Supervivencia; Resultado del Tratamiento; Uridina/uso terapéutico

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Uridina / Enterocolitis Seudomembranosa / Clostridioides difficile / Aminoglicósidos / Antibacterianos Límite: Animals Idioma: En Revista: J Antimicrob Chemother Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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